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A new approach for measuring the trabecular bone density through the echosound backscattering: An ex vivo validation on human femoral heads

TitleA new approach for measuring the trabecular bone density through the echosound backscattering: An ex vivo validation on human femoral heads
Publication TypeArticolo su Rivista peer-reviewed
Year of Publication2016
AuthorsDe Marco, T., Peccarisi M., Conversano F., Greco A., Chiozzi S., De Pascalis F., and Casciaro S.
JournalMeasurement: Journal of the International Measurement Confederation
Volume87
Pagination51-61
ISSN02632241
Abstract

The aim of this paper was to propose a novel approach to the ultrasound (US) characterization of human bones through an improved measurement of the apparent integrated backscatter (AIB). Four intact human femoral heads were studied ex vivo in their physiologic morphological configuration, including cartilaginous, cortical and trabecular regions. Each sample underwent an US acquisition performed with a clinically-available echographic device and a micro-computed tomography (micro-CT) scan, whose spatial resolution was preliminarily optimized for this specific purpose. A dedicated US signal compensation was employed in the AIB computation, to take into account the variability of sample-probe distance and cortical bone thickness. Obtained results showed an appreciable global correlation between AIB and the trabecular bone volume fraction as quantified by the micro-CT parameter BV/TV (|r| = 0.69). The proposed approach has interesting perspectives for a clinical translation as an innovative method for in vivo US measurement of proximal femur bone density. © 2016 Elsevier Ltd. All rights reserved.

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84962812105&doi=10.1016%2fj.measurement.2016.03.011&partnerID=40&md5=41ef29ae140c810ddfe3d5d836946465
DOI10.1016/j.measurement.2016.03.011
Citation KeyDeMarco201651