Infill walls used in existing Italian reinforced concrete (RC) buildings are highly vulnerable and their failure can lead to economic losses and human casualties, mainly in case of seismic events. For this reason, the study of their vulnerability becomes particularly significant during extreme events, such as volcanic eruptions, windstorms, and floods, when the interior of buildings offers protection. This paper discusses the design process of shaking table tests conducted on a full-scale reinforced concrete 3D frame structure. The single-story structure has four hollow brick infills samples, three fully infilled and one with a central opening and will be tested under both in-plane and out-of-plane loading. A six-degree-of-freedom shaking table will be used to apply the seismic load. The reinforced concrete structure has been designed to withstand testing without damage, enabling multiple trials with various infill wall types. Once damaged, the infill walls will be strengthened with lightweight, easily applied systems to test repair and reinforcement solutions suitable for disaster-affected areas that require quick intervention. © 2025 The Authors.