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Modified hydrotalcite-like compounds as active fillers of biodegradable polymers for drug release and food packaging applications

TitoloModified hydrotalcite-like compounds as active fillers of biodegradable polymers for drug release and food packaging applications
Tipo di pubblicazioneArticolo su Rivista peer-reviewed
Anno di Pubblicazione2012
AutoriCostantino, U., Nocchetti M., Tammaro Loredana, and Vittoria V.
RivistaRecent Patents on Nanotechnology
Volume6
Paginazione218-230
ISSN18722105
Parole chiaveActive food packaging, aluminum hydroxide, Anti-microbial activity, Antibiotic activity, Antibiotics, Barrier properties, Benzoate derivative, Biocompatible Materials, biomaterial, Biomedical applications, Chemical compounds, chemistry, Chloramphenicol hemisuccinate, Composite materials, Diclofenac, drug carrier, Drug Carriers, Drug delivery, drug release, Enzyme kinetics, Filled polymers, Food packaging, Food products, hydrotalcite, Hydrotalcites, Intercalation, Layered double hydroxides, magnesium hydroxide, Mechanical properties, Medical applications, Microorganisms, Nano-hybrids, Packaging, Packaging machines, Patents and inventions, polycaprolactone, review, Tranexamic acid
Abstract

This review treats the recent patents and related literature, mainly from the Authors laboratories, on biomedical and food packaging applications of nano-composites constituted of biodegradable polymers filled with micro or nano crystals of organically modified Layered Double Hydroxides of Hydrotalcite type. After a brief outline of the chemical and structural aspects of Hydrotalcite-like compounds (HTlc) and of their manipulation via intercalation of functional molecular anions to obtain materials for numerous, sometime unexpected applications, the review approaches the theme in three separated parts. Part 1 deals with the synthetic method used to prepare the pristine Mg-Al and Zn-Al HTlc and with the procedures of their functionalization with anti-inflammatory (diclofenac), antibacterial (chloramphenicol hemisuccinate), antifibrinolytic (tranexamic acid) drugs and with benzoates with antimicrobial activity. Procedures used to form (nano) composites of polycaprolactone, used as an example of biodegradable polymer, and functionalized HTlc are also reported. Part 2 discusses a patent and related papers on the preparation and biomedical use of a controlled delivery system of the above mentioned pharmacologically active substances. After an introduction dealing with the recent progress in the field of local drug delivery systems, the chemical and structural aspects of the patented system constituted of a biodegradable polymer and HTlc loaded with the active substances will be presented together with an extensive discussion of the drug release in physiological medium. Part 3 deals with a recent patent and related papers on chemical, structural and release property of antimicrobial species of polymeric films containing antimicrobial loaded HTlc able to act as active packaging for food products prolonging their shelf life. © 2012 Bentham Science Publishers.

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84870221369&doi=10.2174%2f187221012803531493&partnerID=40&md5=b30dfc452e3948208aa25c2d739697f1
DOI10.2174/187221012803531493
Citation KeyCostantino2012218