Clouds strongly affect the Earth's radiation balance and hydrological cycle, while remaining a major source of uncertainty over the Mediterranean. The ENEA Station for Climate Observations in Lampedusa provides a strategic ACTRIS site for long-term cloud monitoring and satellite validation under open-sea conditions. This study presents monthly vertical distributions of cloud occurrence and microphysical properties derived from ACTRIS-Cloudnet retrievals during the first 24 months of operation. Results reveal a pronounced seasonal cycle, with minimum cloud occurrence in summer and maxima in winter and spring, dominated by ice clouds. Liquid clouds are less frequent and mainly confined to the marine boundary layer during spring and summer. Retrieved microphysical profiles reveal distinct signatures of ice, liquid, and mixed-phase clouds, together with enhanced variability during convective events, and suggest a possible overestimation of droplet effective radius in mixed-phase conditions. © 2026 IEEE.